Primepalm is a proprietary formula designed specifically for sciatic nerve pain. Arialief appears to be the first major supplement made using the formula. Oddly, the makers of Arialief provide limited information about what’s inside Primepalm, and the ingredient doesn’t actually appear to be listed on the label. However, it appears to be a proprietary form of palmitoylethanolamide (PEA). Primepalm is “specifically designed to relieve sciatic nerve discomfort,” according to the manufacturer, while helping with inflammation, nerve health, and overall sciatic health.

Magnesium glycinate is an absorbable form of magnesium linked to nerve health. Magnesium is crucial for muscle and nerve function. In fact, people deficient in magnesium could have a higher risk of muscle issues, nerve problems, and nerve health disorders. The makers of Arialief specifically added magnesium glycinate to the formula because it “supports nerve function and muscle relaxation” while also helping to calm the nervous system.

Arialief contains alpha lipoic acid, an antioxidant linked to nerve cell health, inflammation relief, and overall nerve discomfort relief. Alpha lipoic acid is known as a master antioxidant because it targets inflammation throughout the body. It’s also a popular diabetes supplement ingredient, and some diabetics take alpha lipoic acid daily for nerve discomfort relief. The antioxidant effects of alpha lipoic acid could extend throughout your nervous system.

Butcher’s broom is a plant extract used in ancient remedies to promote heart health and circulation. Formally known as Ruscus aculeatus, butcher’s broom could help relieve discomfort caused by poor blood flow to the nerves. This effect could help “in alleviating symptoms of sciatica,” according to the makers of Arialief, while also helping with other nerve-related issues.

L-carnitine is an amino acid found in preworkout supplements, post-workout supplements, heart health formulas, and joint pain relief blends. It’s also found in sciatica supplements like Arialief. The L-carnitine in Arialief works by promoting energy production at the cellular level, helping your body replenish and rejuvenate its nerves. Sciatica occurs when inflammation damages your nerves, interfering with signals sent to your brain.

Turmeric is one of the best-known antioxidant plant extracts available today. It works because it contains an antioxidant molecule called curcumin. Curcumin can promote the healing of nerve tissue while also helping with overall inflammation, according to the manufacturer. The turmeric in Arialief is standardized to contain 95% curcuminoids (like curcumin) by weight, making it an ultra-concentrated form of turmeric.

Coenzyme Q10 is an antioxidant molecule naturally found in certain plants and vegetables. Some take CoQ10 supplements daily for anti-aging. Others take CoQ10 for joint pain relief or sciatic nerve pain. CoQ10 is the last listed ingredient in the Arialief proprietary formula, which means it’s the smallest ingredient by weight. However, you don’t need a lot of CoQ10 to exhibit active effects. Arialief delivers CoQ10 in the form of ubiquinone, a version that’s easy for your body to absorb.